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nerdsnipertoday at 6:58 PM0 repliesview on HN

Same here. My cis-male body and brain really does strongly prefer high E2 levels. Just below “growing breast tissue” seems to be the sweet spot. Testosterone / DHT levels matter much less.

Raising E2 a bit basically cured lifelong suicidal ideation and major depressive disorder for me overnight. And it’s been working for 6 years now.

Libido is still fine - my girlfriends are satisfied unless i’m having a very stressful week.