I have one of the originals. It's useful if you do low-level programming a lot, and in a pinch you can also use it as a standard calculator. The biggest limitation is that the screen can only show 8 digits. In binary mode, this can be awkward if you're working with variables that are more than 8 bits. The calculator has functionality for scrolling around the number that's being displayed to try to work around this, but it's still a little annoying compared to newer calculator designs that can show more digits at once.
What would you use it for? I’ve done plenty of 16 bit hex math back in the day so I can see some level of handiness there, but never quite got what it was meant for, or why someone would want a physical device for it. However, I’d love to hear more!