In CL and Scheme, it's (let ((var1 val) (var2 val)) body...). So parentheses are used for grouping and function/macro application. In Clojure, parens are just used for application, so you have e.g. (let [var1 val var2 val] body...), or (defn foo [x] ..) or (cond testa 1 testb 2 ...).

It takes some getting used to, and I do wish Clojure would do something more like (let [[var1 val] [var2 val]] ... .. though of course then you'd have to figure something else out for destructuring.