Seems like these structural integrity problems are always inside the Russian section. So if you're on a Russian mission to Mars, yes it would be reasonable to be worried. Otherwise this seems like a non-issue.
Unless your spacecraft is built by Boeing.
We had two astronauts stranded in space for the better part of a year just last year!
>Otherwise this seems like a non-issue.
Except you forgot to mention an epic leak in Destiny just three years after it was attached to the ISS: "At its highest rate, the station was leaking about 5 pounds of air per day overboard." [0] Imagine that happening on the 4th year of American Mars mission.
Also, if you on American mission to Mars, it would be reasonable to worry about cooling system dying mid-flight requiring three spacewalks to fix it: "We'd lose cooling capability to half of the electronics on the U.S., European and Japanese part of the space station." [1]
Ah yes, the well traveled and highly tested human mission to Mars.
This is just not true. There have been leaks due to micrometers in just about every section of the ship at one point or another. A quick search pulls up examples of US modules having issues, especially around interfaces and seals. NASA had a whole investigation between 2018 and 2021 about the recurring issue.