Random thing I ran into while trying to seed search for a challenge run, but since the seed is passed through a 32-bit hash function it means there's effectively only 4 billion seeds (as opposed to the first game, which had 64 bit seeds). This is great if you wanna do something like prove/disprove whether there are unwinnable seeds since its trivial to brute force all of them, but it does mean the potential for fun "high roll" seeded runs is much lower, which is a shame since the new game has so much more variance than the original.
This was the challenge run I ended up with (Ascension 10 win without taking any cards) https://youtu.be/PbP284CZrZ4?is=iL1E7gIzj_kgx0MS