Yeah those low core global system variables (including a readable/writeable 0) at fixed addresses were very much a thing, they were a bad design decision made for the original Macs with almost no memory, and made running more than one app (switcher/multifinder) a difficult transition back in the day. Someone wasn't planning ahead

I also worked on the original A/UX port for the Mac II, some hardware (like the IWM) required tiny buzzy loops, we ran into one bug where using the floppy caused ADB to freeze, but only on the release machines, not the prototypes all our engineers had, turned out there was hardware that made access to the VIA faster by pulling the clock in for 1 cycle, if you sat in a loop reading the timer in the via to measure a sector time for the IWM in too tight a loop it upped the output clock from the VIA to the ADB chip and over clocked it ....