In normal use, we don't expect fast refresh to significantly reduce an E Ink panel's lifetime.
The E Ink material itself is long-lived, the main stress is on the driving electronics and waveform behavior during refreshes. Our approach doesn't add extra refresh cycles, the display starts responding sooner, which improves perceived speed without adding extra refreshes.
So far, fast refresh hasn't been the dominant failure mode in our testing. Physical stress, bending, pressure, heat, and moisture are much larger risks.
On eye strain: E Ink is reflective and bistable, so a static image doesn't require continuously emitted light. Fast updates can still produce artifacts like flashing, dithering, or ghosting, but that's a different issue from a display that continuously flickers.
So I'd say this addresses an important part of the problem, though comfort will vary by person.
Also I recommend checking out the following resources: