alt Hacker NewsHeavy life challenge: Biology usually discriminates against heavy isotopes. Can we reverse, redirect, or exploit that tendency? Find a way to get plants and bacteria to preferentially incorporate heavy atomic isotopes.
Use microbes, algae, duckweed, or plant-cell cultures to produce deuterated and 13C/15N-labeled complex biomolecules that are expensive or impractical to synthesize chemically.
Could be fun, honestly.
I know you're joking, but changes in isotopes mildly affect reduced mass and hence enzyme kinetics. Maize and other C4 plants already preferentially enrich themselves with 13C [0-3] which occasionally buggers up metabolomic experiments. Famously, a few drugs use 2H rather than natural abundance H typically in order to exploit a kinetic isotopic effect and get a better Km in their binding pocket [4].
[0] https://en.wikipedia.org/wiki/Fractionation_of_carbon_isotop... [1] https://pubmed.ncbi.nlm.nih.gov/7577891/ [2] https://pubmed.ncbi.nlm.nih.gov/1734681/ [3] https://en.wikipedia.org/wiki/List_of_C4_plants [4] https://en.wikipedia.org/wiki/Deuterated_drug#Examples