I don't have the right setup to make good benchmarks for this right now, but when I had the chance to put it into practice, the improvement between no cpu alignment and full alignment was quite large. That was on a 28 core machines (with 16 nic queues); many years ago, but IIRC, I got at least 10x the connections/sec out of the boxes after tuning and after tuning 12 cores were idle ... the machines were repurposed, if they were ordered for this, they should have had one core per nic queue in a single socket. The difference is likely smaller on a 4 core machine as described in the article.

The hardest part is going to be generating enough load. I had production load, which has the benefit that you don't need to generate it. Otoh, it was a transitional need, and I couldn't reasonably test above 50% of peak traffic on a single machine ... I hit that mark around the time traffic started dropping, and then it wasn't fun anymore.