I reboot one of my machines all the time. It's a Mac Mini running 'Little Snitch', which informs me about all of the network connects my apps make, especially browsers. One cool feature of that program is that one can temporarily grant access to a connection, for instance until the request quits, or one logs out, or one restarts a machine. I'm slowly developing permanent allow / ban lists, but I also use this feature to temporarily utilize some website, aand then reboot to avoid cross-contamination.

The downside is that I often get shunted off into additional authentication workflows, since the prolonged delay caused by my manual approvals triggers some alerts. One of the entertainment ticket buying services is really convinced I'm committing some kind of fraud.

So, in general, I reboot everytime I start using that machine, at least once per day, sometimes more frequently.

Fun fact: in a former life, I worked for a retailer with 1000s of remotely deployed machines and no field-based tech support. One of the OSes we used back in the day had a bug that caused their license authorization service to fail after a certain amount of uptime. We had hundreds of machines that reached that uptime, all on the same day. Suffice it to say, that was not fun.