The first early human eggs from stem cells

This is a good tech to have, with applications both in IVF and in research.

Currently, egg retrieval is a significant part of the IVF process - one that's notoriously taxing on the women. Once this gets refined enough for clinical uses, it can become as simple as "take a blood sample once, produce as many eggs as you need". With an added benefit of being able to get eggs when traditional retrieval fails.

Related (2021) Turning stem cells into human eggs (97 points, 102 comments) https://news.ycombinator.com/item?id=29040823

This is how the clone wars began

Very impressive work!

(Hmm, I wonder if this can be done for chicken eggs)

To confirm, we get a clone of the blood donor right, whether man or woman?

How hard you have to work to break scroll on web page? Nice article, but going through it was a technical nightmare.

Can we stop adding unnecessary JS to website to stop global warming by calculating AND ALTERING SCROLL?

I am worried about the long term impact of research involving human conception, IVF, etc.

The reason is that genetics/evolution don't yet seem to fully explain how humans exist. A computer genetic algorithm run for a billion generations doesn't lead to anything anywhere near the the complexity of a human.

I suspect there are as-yet undiscovered effects which shape the next generation. Whether that be DNA methylation, gut bacteria passing from mother to child, selection of the 'correct' egg or sperm out of millions, or something new and un-discovered etc.

And if those effects are bypassed with artificial conception, we might end up with humans which aren't as strong, aren't as smart, aren't as well adapted to a changing environment, etc.

The effect will be small for each generation, but after 5-10 generations of a combination of artificial and natural conception you could end up with meaningful loss of fitness - or perhaps a lack of gain of fitness that would have otherwise occurred.

That can't be good. Life cycle of a human egg is organized around preserving mitochondria to be as young and fresh as possible across generations. Using adult cell, even a stem cell to make an egg probably gives it mitochondrial damage that usually takes hundreds of human generations to accumulate.

A japanese scientist again (Katsuhiko Hayashi is in Osaka).

Shinya Yamanaka created iPSPs in 2009:

https://en.wikipedia.org/wiki/Shinya_Yamanaka

Guess the japanese excel at micromanaging. Although one could say that the research here in the article is more epic than Shinya's discovery, but I remember having watched one of his presentation and it convinced me of pure epicness, if you understand how his team found the "Yamanaka factors". That was by human (work) consistency. About as epic as Christiane Nüsslein-Volhard and her mutant screens, that also involved tons of micro-experiments.

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Imagine guys like Musk, Bezos, Zuckerberg or Thiel cloning themselves. That's 100% dystopian. We would never be able to get rid of madmen! Power corrupts and makes the powerful just weird and unable to make rational decisions. That's why people in power need to be replaced regularly to have a stable society.

We need less people not more.

I'd be very curious how they even define "safe enough" for this. With most therapies, the risk is mostly to the patient. Here the risk could be passed on to a future person who never consented to the experiment.

The origins of stem cells for use in the biosciences and in cosmetics are extremely brutal and should be illegal. Sandra Bullock explains it better than I could: https://youtu.be/PwO3TEj9-5g