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rf15today at 6:37 AM2 repliesview on HN

genuinely curious: how does any life still exist if this holds true?


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jmcgoughtoday at 8:29 AM

I think they're arguing that a somatic cell from an older human contains mitochondria that's more degraded. Egg cells are all created before birth, and each is pre-seeded with a large number of mitochondria.

scotty79today at 6:48 AM

When the damage accumulates across generations the natural selection has opportunity to weed out particularly harmful instances. You can get a feeling for how important avoiding the mitochondrial damage is and how hard it is to mitigate, by looking at how fiercely the reproductive process protects them from aging.

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