I've read than even a lot of high school biology questions can set off safety guardrails on Claude.
I'm curious what you asked? I had Opus 4.8 ingest the URL and give me some ideas about what's possible and it eventually got to AI and self repairing/improving factories along with listing risks etc.
A lot of high school biology underpins the most immediate interesting aspects of chemistry and biology, and also the most volatile and dangerous ones.