alt Hacker NewsA major confounding factor is everything else in the air. Humans produce lots of different gases, and CO2 is usually a proxy for the overall concentration of our effluent gases. But in a submarine, or in some buildings, there are gas filters (usually carbon, possibly with various modifications) that can remove or destroy some of these gases but have no effect on CO2. So the air in a submarine at 15000ppm CO2 could be very different from the air in a an unventilated room that reaches 15000ppm CO2.
The first person to deal with this may have been Cornelis Drebbel in 1610 when he deployed the first submarine. With 4 oarsmen submerged in a leaky wooden sub, they’d have too much co2 and too little oxygen. Somehow they were able to stay for hours at a time.
Robert Boyle describes Drebbel’s use of a “chymical liquor” to refresh the air.
“Paracelſus, indeed, tells us, that "as the ſtomach concocts the aliment, "and makes part of it uſeful to the body, rejecting the other; ſo the "lungs conſume part of the air, and reject the reſt." Whence, according to him, we may ſuppoſe a little vital quinteſſence in the air, which ſerves to refresh and reſtore our vital ſpirits; for which purpoſe, the groſſer, and far greater part of the air, being unſerviceable, it is not ſtrange that an animal ſhould inceſſantly require fresh air. This opinion, indeed, is not abſurd; but it requires to be explain'd and prov'd: beſides, ſome objections may be made to it, from what has been already argued againſt the transmutation of air, into vital ſpirits. Nor is it probable, that the bare want of the generation of the uſual quantity of vital ſpirits, for leſs than one minute, ſhould be able to kill a lively animal, without the help of any external violence. And, upon this ſuppoſition, Cornelius Drebell, is affirm'd, by many credible perſons, to have contrived a veſſel to be row'd under water: for Drebell conceiv'd, that it is not the whole body of the air, but a certain ſpirituous part of it, that fits it for reſpiration; which being ſpent, the remaining groſſer body of the air, is unable to cheriſh the vital flame reſiding in the heart. So that, beſides the mechanical contrivance of his boat, he had a chymical liquor, which, by unſtopping the veſſel wherein it was contain'd, the fumes of it would ſpeedily reſtore to the air, foul'd by reſpiration, ſuch a proportion of vital parts, as would make it again fit for that office; and having made it my buſineſs to learn this ſtrange liquor, his relations conſtantly affirm'd, that Drebell would never diſcloſe it, but to one perſon, who himſelf told me what it was.“
https://sourcelibrary.org/book/philosophical-works-vol-2-boy...