2 Settings I change on every htop which makes a HUGE difference.

1. I disable user threads. Those mostly just clutter up the htop view while providing no useful information.

2. I enable the process tree view. Very frequently, where a process comes from is much more important than other information. It also lets you see and track things like a compiler process which is eating through a bunch of files.

IMO, both these things should be the default behavior of htop.