UV, Ruff and Pyrefy and you're set. As someone who works with Python, Typescript and C/Zig quite a lot I don't disagree with you on Typescript, but I'm not sure why you'd pick Typescript over Python. Bun is kind of awesome, but it's also kind of unfinished, but if you go with the default Node I find that the setup for security compliance is next to impossible where Python can do most things with it's standard library, a pandas and pyarrow.

I personally prefer the fake typing in Python because it fits well with our defensive programming style with very low abstraction and little to no adherence to DRY. Since Python naturally force you to deal with runetime assertions rather than getting you to do compiletime checks that then don't actually offer any form of safety at runtime. Which is obviously not a very technical argument, but it just feels a lot cleaner rather than having to juggle the two.