Personal laptop use with Ada Lovelace or Ampere family NVIDIA GPUs (did you mean this or CUDA, i couldnt tell), personal desktop use with unusual peripherals, dependency on ports, existence and competition of FreeBSD etc. I love OpenBSD's code philosophy (they were the first to introduce a lot of security techniques[1]) and the programs they produce, OpenSSH is a lifesaver, and I use doas for its low footprint on my Linux machine. Still, they have a convulated install process, dubious hardware and software compatibility that is better solved in the Linux world today.
So pretty much only GPU compute (CUDA) and exotic peripherals?
I don't see any ports dependency issues as there's been binary packages available forever. Even the install process is a lot faster than any linux I have to use at $work, not to mention easier to automate with autoinstall[0] if needed.
[0]https://man.openbsd.org/autoinstall.8