> Wouldn't a counter this argument be biological systems? These are reasonable points as long as we are talking about current methods, but I assume if we were to get to the point of self replicating probes it would be done by something like nanotechnology, synthetic biology like systems.

Biological systems require extremely specific environments that aren't space.

Yeah, you can self-replicate (well, not exactly self-replicate), but just think of all the "infrastructure" you need to do that: massive volumes of air and water, all kinds of weird chemicals not found in minerals, a whole biosphere of other stuff, a literal star, etc. And none of that infrastructure is really space-worthy on any reasonable scale for a probe.

If you broke it all down, I bet you'd need a mass/volume at least as big as a more technological probe. And you still need the technological infrastructure to build a vessel to hold it all together.