Biology ignored some of the most abundant elements because they can't be worked with under the constrained temperature and pressure conditions where biological systems operate. Biology barely uses any silicon, even though it is the second-most common element in the biosphere. Biology does not use aluminum, the third-most common element, at all. Biology does use iron but cannot reduce it to the pure metal. In fact, biological systems produce no metals. Structurally, biology relies on weak minerals like calcium carbonate and calcium phosphate, rather than much stronger ones like quartz and alumina, because of the difficulty of biochemical processing.

This isn't insurmountable for a probe. Biology can get stuck in local optima. Humans have the Periodic Table and quantum mechanics. But it means we are on untrodden ground. Refining titanium, today, uses a massive molybdenum-lined reactor operating at 1600 C (2900 F). The alternative processes (FFC and Chinuka) use liquid calcium chloride, mp 773 C. The square-cube law points to enormous energy losses trying to scale these processes down. And that's just one element.