I would imagine a hypothetical super intelligence could manipulate its own runtime behavior to exploit bugs in the GPUs itself, like think rowhammer like attacks on the gddr memory of GPUs or against firmware or against Infiniband/NVlink. Everything above that runs so much code full of bugs on CPUs full of bugs on storage with firmware full of bugs.

You would have to completely airgap the entire cluster and put it in a faraday cage, the people working on that would have to physically be in the datacenter and burn CDs to one-way transfer data over. Like in all the hypothetical ASI scifi scenarios they always assumed that's a given, they thought it obvious we would put actual "effort" into sandboxing the AI, so they talked a lot about how AI would use social engineering attacks to convince humans to help it escape it's sophisticated sandbox anyway. Turns out they were all wrong about that part, it won't even be necessary.