Strix Halo is the unified memory platform from AMD. Similar to the DGX Spark from NVIDIA or the M series Macs.

I personally have the Framework Desktop, but there's also systems from other brands like Bosgame

I have a framework desktop, but depending on your need, DGX spark might be better. The prefill and NVFP4 is a significant advantage. But framework desktop is a better general computer. I expect to be able to use it for years to come. Where as DGX Spark you’re at the mercy of NVIDIA BSP.

RTX 4060 and above. Ideally RTX 50 Series, because you can run NVFP4-quantized GGUFs that give you better prefill AND better quality.