RC4 is a good example of what Aumasson means when he jokes about weak symmetric cryptography being a quirk of history. It's genuinely weird that RC4 was as popular as it was! DES is broken because it's small, with tiny keys and an 8-byte block. But if it had 16-byte keys and blocks, and presumably a higher round count, the only dealbreaker with it might be that it'd be slow.