No, the stuff it encountered during its millions of years of evolution is not the "monkey wrench". That is its legitimate input. Those are the things that it evolved with. Those it can handle fine.

And instead I meant all the stuff that is used to elicit a specific response using some incidental behavior. Those were not part of its evolutionary journey. Those it won't be able to handle and would result in un-predictable regression. That is the monkey-wrench throwing.

>And it's far from perfect at all.

A large number of living things on earth live to their entire lifespan. I think in those cases the immune system did a perfect job.