his bad investments and obsession here was certainly something that brought him down, but I'm going to have to say what probably really ruined his life was his daughter Susy Clemens dying of spinal meningitis in 1896, 2 years after the bankruptcy.

As someone with some familiarity with Clemens, and stresses piled upon stresses, I feel it is somewhat insulting to the man to think he just couldn't handle losing some money and having his entrepreneurial dreams not work out, because really that is some minor stuff right there, and in the end he was still one of the most popular writers in the world, it was going through the stress and then getting more on top. Especially, as it is my experience, when you are going through something really difficult and are at your weakest, people try to take advantage of that. It would not have been a good therapy for his misanthropic bent.