As opposed to loading it up in RAM + VRAM? Pretty much always better to split it up to multiple GPUs. My priorities are load up all available VRAM, then offload MoE experts to RAM (if possible), then offload other layers.

I use an RTX 3090 (24GB) and a GTX 1080ti (11GB). Just the 3090 for 3.8 I get maybe 60tg/s (UD-Q4 quant), for both I get around 40tg/s (UD-Q6). Not apples to apples though considering it's different quants.

Here's my config: https://gitea.va.reichard.io/evan/nix/src/branch/master/modu...