If you look at the definition of a macro like defcustom, you'll see that it just expands to a function call, where all the logic is implemented. This could also be implemented in the macro, but that is more complicated and brittle, due to the risk of double-evaluations and having to produce code that will (usually) later evaluate with the intended side effect.

Furthermore, macros and functions constitute a kind of function coloring. To use a macro in a function, like defcustom, you couldn't pass the name of the user option you are defining in as a symbol, as that is not evaluated. So instead you'd have to call eval on a runtime constructed expression, which is a cludge.

So I agree with the top comment, to avoid macros is a sign of Lisp maturity. It is easy and fun to admire them when you are coming from languages with arbitrary restrictions in their macro systems like C, but ones you get used to them you don't treat them with any more wonder than any other arbitrary restriction that a language may lack (bad ad hoc example: nobody praises C for the lack of a CALL keyword).