Not if you just stick to the basic built-in 30-year-old HTML GUI elements (<button>, <select>, <legend>, <form>, <input>, <table> for layout, etc., maybe also some modern standards like flexboxes) which are very fast, lightweight, east to code, and uniform. The problem to me is every website tries to do some custom javascript monstrosity with their own graphics to keep up with the latest fad. When just sticking to the basics, I find the web is a great cross-platform GUI framework.