If you can use a custom chip yep, if it's commodity hardware probably not. You could use secure boot/secure memory etc but that can be a footgun in itself later.
What do you mean "Custom chip", like ASIC ? Never in my career that i feel the need to make our own ASIC.
What do you mean "Custom chip", like ASIC ? Never in my career that i feel the need to make our own ASIC.