Whether they make economic sense or not depends on launch costs. With current operational rockets (such as Falcon 9), the launch costs are too high for space compute to be profitable. All these projects depend on Starship succeeding. If you read Starcloud's white paper[1], they make the case that space data centers can be cheaper than terrestrial ones because of access to 24/7 solar power. I think failure is more likely than success for Starcloud and similar startups, but conditional on Starship lowering launch costs, it does look like the idea can make money.

1. https://starcloudinc.github.io/wp.pdf