Unless you have some kind of dynamic DNS with a background daemon, you'll be bothered by NAT eventually. And even then it's hardly as convenient. With Tailscale, I can sit on a rooftop bar in the Medina of Marrakech, connect my phone to the public WIFI, and access my laptop in the hotel WIFI across town. Or production infrastructure on a highly secured server somewhere on the other side of the planet. All without compromising security, and all devices involved just pick the shortest physical link to each other.

It's really pretty cool.