Canada is already mostly through, setting up trade agreements with the entire rest of the world. It's amazing what can be accomplished, when it's clear that everybody wants to bypass a certain country.
The whole world is going to trade with each other, and just ignore the United States. It'll be a rough five to ten years of transition, but there's been lots of economic situations like that. The US is the past, it's relevance waning.
The US is also far more vulnerable. It's 90% of the way to a civil war already.
Alberta has been going on for decades.