Wildfire smoke will be the big question there. It's started to be bad for a week or two a year in Minneapolis, and is only worse the closer you are to the boreal forest.
And the failure of basic services like water and power.
Given it took FEMA ten days to get power restored to the super dome, how long will responses be when there are many simultaneous disasters of that size or bigger? With the current admin the answer could be “indefinite”
Wildfires only a problem until the overgrowth is burned off. When there's not enough to sustain a large spreading fire, they will stop happening.