'Fuel efficiency' is not the bottle neck to getting more clean energy on the grid, scale is. Waste? grind it up, vitrify it, bury it in an abandoned coal mine or something. People get more radioactivity from a coal power plant than they will ever get from properly handled nuclear waste.
It sure is. If the world were nuclear powered (all energy, not just grid) with burner reactors, estimates of uranium resources (not reserves) at up to 3x the current price would last about five years.
A fully nuclear world needs to use nuclear fuel efficiently, which means breeder reactors.