Yes it works great with them through Vulkan. ROCm is more hit and miss, especially because the cards which are affordable (and PCIe, the new ones aren't PCIe compatible!) are already fairly old and have already been dropped by ROCm.

But Vulkan is actually faster too so there is no reason to bother with ROCm anyway.

I don't currently have an actual datacenter card, but I have a Radeon VII Pro, which is basically a 16GB version of the MI50 Instinct with its own fan.