there is currently no linux distribution where it's safe to run an application as is. they tend to have access to /home which is game over.

some people who actually care about security will create bubblewrap/bwrap profiles for applications and then run those profiles. an application isolated in this way will have a limited view of the system much less the ability to modify it. it usually takes the form of a custom /home for every app.

this still leaves the kernel exposed for an application to poke at and maybe escape with a 0day. some people run a VMM to further isolate the application, these days you can passthrough Wayland. if the application isn't graphical you should probably use gVisor instead.