Have you actually hear him talk about it? It is very far from rambling and he will be the first to tell you that he is not sure he is right.
We need physicists to come up with and develop novel ideas to consider no matter how many of them might be entirely wrong.
There's a difference between making and testing hypotheses, and desperately scrambling to find proof to justify a conclusion made in advance in the face of mounting evidence that said conclusion is false, which is what Penrose is doing regarding quantum consciousness.
Grossly simplifying: he is a dualist, he wants to reconcile his belief in the soul and his physicist's materialist view of biology, so he resorts to putting the source of consciousness in quantum phenomenas, and seeks to prove that they occur in the brain. I disagree that there's an immaterial soul, I disagree that it puppets the material universe through quantum phenomenas, and I disagree that there are important quantum phenomenas in the brain. Most physicists are with me on these.
If mind was random, people would miscalculate 1+1 with 50% probability. So earth might be flat, but it's unlikely.