alt Hacker NewsAnd various dedicated AI models all made poor predictions of the results of that experiment, which casts doubts about the value of the AlphaGenome predictive map.
A virus is much simpler than a human, but even for that simple virus the effects of most of the mutations could not be predicted. A half of the mutations had harmful effects, and for a half of those it is unknown for now why they were harmful.
For a human the uncertainty about the effects of a mutation will be far greater than for one of the simplest viruses.
> A virus is much simpler than a human, but even for that simple virus the effects of most of the mutations could not be predicted.
Is this the correct logic? I (very naively) would think that a small mutation of a virus, with the percent change that is being made, would be more of a fundamental change in the nature of the thing, so maybe less predictable. Where poking genes of a human being more of a (possibly strong!) statistical nudge, since most things seem to be spread across many genes, what's being expressed for sometimes environmental reasons, and even influenced by "junk DNA".