> I watched an interview that Casey Muratori did with Tyler Cloutier (SpacetimeDB founder and spokesperson) [1]. One of the points that Tyler is that, given modern CPU architecture with cache lines, a distributed database needs to fan out to at least 50-100 nodes to beat the throughput of a cache-optimized, single node database.

Do you have the timestamp where they are talking about this? The claim doesn't pass the smell test for me. If you're talking about latency, then perhaps. On throughput, I don't understand how a single-node system could deliver higher throughput than a three-node system