Well given "therapeutic index" I had said "medication" as opposed to "commonly abused substances". I think your list skews heavily due to psychedelics tending not to be acutely toxic to the same extent as other chemical species.

Statins for example are probably 10x to 20x (quick napkin math based on an animal study I found). Tylenol is 10x and is OTC.

Personally I consider alcohol to be much safer than many other substances given the form it typically takes. Utterly irresponsible binge drinking aside, most people will suffer serious adverse effects long before they're in danger. Compare that with pills or injections where an OD can be entirely inadvertent even when observing basic common sense.