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nomeltoday at 12:44 AM3 repliesview on HN

For example, 45% reduction in symptoms from fecal transplant: https://news.ycombinator.com/item?id=48158494

> Prior to the study, 83% of participants had "severe" autism. Two years later, only 17% were rated as severe, 39% as mild or moderate, and incredibly, 44% were below the cut-off for mild ASD.

Incredible! Sure, there could be a genetic component to what flourishes, or ever seeded, in one's microflora, but there's definitely some external complexities involved here.


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dns_snektoday at 8:25 AM

The study that found a 47%* reduction (relative to symptoms at the start of the study) wasn't placebo controlled and had a sample size of just 18, so there's not even a control group to compare against.

> We note that due to the open-label nature of this initial trial, all of the assessments are subject to placebo effect, however the long-term improvements we observed here are promising.

https://www.nature.com/articles/s41598-019-42183-0#Sec2

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bcjdjsndontoday at 8:53 AM

> Prior to the study, 83% of participants had "severe" autism. Two years later, only 17% were rated as severe, 39% as mild or moderate, and incredibly, 44% were below the cut-off for mild ASD.

It just says they behaved better, that's not recovering from severe autism at all... They didn't magically acquire language from a fecal transplant. Misleading

donkey_brainstoday at 3:32 AM

Of all the misguided, abusive studies. It beggars belief that a board somehow approved this.

What happened here is simple: the autistic kids got better at masking in order to placate the researchers who were shoving poop up their butts. In the hope of making it stop.

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