Being an owner of Apollo V4 ITX UEB, I wondered what about 68080. With 64-bit and AMMX vector extensions. But the website briefly mentions "and on today's accelerator hardware". MiniMig is also not mentioned, but at least PiStorm is.

With regards to 68080, the toolchain that can make use of all features of 68080, is based on some old GCC and currently hosted on Linux amd64 which is a shame. And if original Amiga target is desired, this toolchain can do it too, and it is told to be more optimal than other compilers, especially self-hosted ones. GCC first lost ability to run on Amiga, then lost ability to generate m68k code.