In lots of scenarios I know the software used to generate the key; the only unknown is the random numbers used. If I am searching for weaknesses it is highly likely I would try keys with different seeds; zero, one, are going to me much more likely choices here then hoping I can guess the right values.
If the keys are selected uniformly at random why are 0 and 1 more likely than other values?
If someone was using RDRAND16 to seed a PRNG, choosing to omit one single value (a zero) from the return value would not significantly improve the generated values, if at all.