Give it a go, I don't know anyone who has converted back (n=3). Agents/LLMs make things much easier these days.

If you have a single machine and only use stuff from the official nixpkgs, there are no more struggles than any other linux distro, this is a very happy path (imo).

Going outside of that you will, practically, need to convert to using flakes. The conversion is easy, but its another learning curve and there are conflicting docs. Agents make short work of this.

Packaging things yourself can get quite hairy. For simple projects in a single well supported language its easy and just a couple lines of code. For a rust+wasm+solidjs+vite+julia+more monorepo, it was a couple of weeks on a steep learning curve. Agents are pretty okay at packaging in general, I've been able to oneshot a number of difficult-for-me packaging problems, other times it can be an unmitigated mess.

For remote deploys, secrets management, and other devops-like tasks, things get harder, but most people don't need/want this and if you make it this far the remaining learning curve is totally worth it.