That AmigaDOS emulation will almost certainly never run another program. (-:

Far more concerning from a RISKS point of view is the spare parts being physically in the same place as the live machine.

> Just another program poking memory it’s not supposed to. Not even necessarily maliciously.

What other program? Most DOS versions were not multi-tasking beyond "terminate-and-stay-resident" (TSR) programs like mouse drivers.

Whatever application you ran on DOS was THE application your computer was running.