Not any longer. Back in the mid-2000s the company I worked for sold point-of-sale systems based upon a multi-user 4GL application (TAS Pro). Similar to dBase/Clipper etc., using the Novell Btrieve ISAM database engine.

With the advent of USB and SATA we ceased to be able to source industrial embedded x86 boards which could run the application. At the time this was with Novell DR-DOS, which was relatively modern in terms of hardware support but still behind the times and we were struggling to manufacture new systems. The company was very small, so a full rewrite was investigated--I did a prototype using PostgreSQL and Gtkmm--but it wasn't realistic. Today, an AI could probably do a full rewrite in a day or two, including migration tooling. Back then, it would have been a multi-year effort for one person given the application's size and complexity.

My solution was to run Linux since it had full support for the hardware. Debian Sarge at the time. This used a Perl frontend and dialog(1) to present a simple menu system at startup. This did backups, software updates (over dialup!), remote access for support (again over dialup), ran backups and ran the main application. It would start DOSEMU which provided the application with VGA display, COM ports and parallel ports for the application to drive "directly" (from its perspective). It also used Samba and CUPS to provide the DOS environment with shared network drives with exclusive byte-range file locking needed for the multi-user network database to work with concurrent users without data corruption, and also multi-user report printing and receipt printing.

I left the company a year after this was put into full production, but the last I heard it kept the company viable with a supportable product for many years after until its owners retired. This kept software from the early 1990s running well into the 2010s, and there are likely still sites running it to this day.