Worry more about the financial incentives built into every nook and cranny of our economic system to the point it permeates scientific funding, that make it an asymmetric bet to say anything even if it is proven wrong later, than to spend a lot and say in the present, "I got nothing". Modern science is more an industrial complex where errors and overstatements are often the rational outcome of perverse economic incentives. More commonly known as publication bias or the file drawer problem.