> Do we currently have the ability to do targeted methylation or de methylation at sites in cells?

No, and you probably wouldn’t want it if you could. You don’t know what mutations are lurking in the genes that have been switched off or the consequences of turning them back on.

I’ve thought about this a bit, and what resetting the methylation map really requires, in addition to actually resetting that map, is resetting your genome to a known good state.

That’s pretty radical, but to selectively switch methylation on and off with precision you’re already talking about science beyond anything we have, featuring custom engineered constellations of proteins that unwrap your chromatin from around histones and then walk along it changing methylation state, then pack everything back.

And doing it for each cell type, without applying the wrong map anywhere.

And knowing what all the cell types and their correct methylation maps actually are.

And assuming that methylation isn’t used anywhere, for example in the brain, in a way we don’t expect.

And methylation isn’t the only kind of epigenetic modification.

So, if we’ve solved all of those problems, rebuilding your DNA to a clean, mutation free state at the same time should be a breeze.

We really do need AI for this if any of it is going to be remotely feasible.

Good news! Research shows that hope reduces stress! [0]

[0]: https://www.forbes.com/sites/tracybrower/2024/09/15/how-bein...

I just don't understand. Wouldn't we have evolved in an environment with constant stress? Constant fear of disease, starvation, predation, attacks by neighboring tribes? Why would our body's natural response to our environment be to immediately grenade itself.