alt Hacker News“ Arhgap36 is known to cause developmental problems in other animals when it is over- or under-functioning. But it seems that in orange cats, the gene is overexpressed only in developing and mature pigment cells called melanocytes.”
This doesn’t make sense… if thousands of anecdotal reports in cats specifically report otherwise? And if it’s known to not be limited to melanocytes in other mammalian species?
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Only an anecdote, but our orange cat doesn't really conform to any of the stereotypes. He so smart he taught himself how to open doors.
There's the "my anecdote trumps those scientists facts" guy. Never fails.
Humans carry this GTPase as well. GTP is energy source of receptors called G protein coupled receptors. They are about 750 these and many of them are catecholamine receptors, like the serotonin and dopamine receptors.
Humans also carry this gene. https://www.uniprot.org/uniprotkb/Q6ZRI8/entry
In humans, both DNA and RNA are mostly expressed in the brain and in the endocrine system.
https://www.proteinatlas.org/ENSG00000147256-ARHGAP36/tissue
For cats it very well may be different. Genes do not express activity the same indifferent species and they’re definitely not the same in different parts of the body. Genes can express RNA in one part of the body and more DNA and another part.
But I think this deletion is really about how it affects the methylation the gene.
Wait until you find out about the thousands of anecdotal reports from parents about “sugar rush” in their kids- also without foundation
people are very good at seeing their pets conforming to their expectations, whether that is scientifically true or not :)
https://www.sciencenews.org/article/dog-breed-individual-beh...
> Breed offers little predictive value for individuals, explaining just 9% of variation in behavior.
https://www.science.org/doi/10.1126/science.abk0639
https://www.scientificamerican.com/article/which-dog-breed-s... (here note how big the overlap is between breeds for most traits, and clumpiness is rare, but present)