Its easy to be surrounded by enemies when you keep giving them reasons to hate you.
It isn't really unique to Israel, though. There's conflict practically everywhere where major cultures/religions have drawn up borders, or within the backwash of fading empires (Britain, Ottomans, Soviets, French...).
You're right. Never in history and never anywhere else in the world have Jews been persecuted.
Palestinians aside, what reasons do neighboring countries have to hate Israel from it's very first moment?
A lot of the immediate neighbors attacked Israel at its birth, and further away countries just seem to hate Israel due to religion/ethnicity/populism (?), countries like Pakistan, Malaysia, etc.