> Is she truly the most manipulative person we've ever seen

Probably no. The most manipulative are still not in the jail and are running some well-known big companies.

I haven't seen it, but my opinion is she likely was what lawyers call "reckless", as in she should have known but didn't care (blinded by the upside and a "we'll figure it once we scale" tech attitude that works a lot better for db performance than healthcare).

Does the film address that thing she does with her voice?

Best take of the movie here. When the whole crew met with them before production, Nathan's idea to say "fuck it, let's just see how they do business" was the right call and might show she actually may not have known as much as you'd think, but it's fully intentional to the point of complete insanity.

I think if you're stuck on that question, her manipulation poked through the silver screen and worked on you.

To me the subtext of the movie was that a sociopath's manipulation is so strong that even against the heavy counterforce of the filmmaker's bias, it makes it through. I agree with TFA's general premise that the film forces you to confront how easy it is to deceive you -- but it's not the filmmaker who's doing the deceiving. Sociopathic manipulation is about sparking doubt. Gaslighters don't need to prove anything, they just need to plant a "but what if" in some corner of your mind. The fact that the author felt compelled to write TFA at all is ironically a product of that manipulative power.

Another way to think of it is: the documentary makes you think whether, if you were in the room with her in the years that Theranos was operating, would you have fallen for it? If you feel the need to write apologia after watching a documentary that's basically a hit piece, you know the answer.

I have no idea what this movie is actually about. I only know Holmes is a classical sociopath. Knowing what that means I cannot imagine any surprises coming from this movie.

Here are key observations of sociopathic personalities:

* They are never wrong, but there are rare times they will admit to being wrong if they have calculated an advantage in doing so.

* They don't care about you, or anybody else. They can't. A sociopath is a damaged personality that cannot empathize. What's interesting is that introspection is the same skill as empathy, so they cannot do that either. As such, they have no faults.

* Sociopaths tend to be charming. They want to appear pleasant. A primary goal of any narcissist is admiration. This is all temporary though, because they lack the empathy necessary to adapt and build trust or extend relationships, which means they are more important than you. It also means they will extend an irrationally great amount of energy to inform you of just how charming they are or how wrong they aren't.

* Sociopaths tend to become hostile when they don't get want they want. They live in a world of "i want" or "i don't want" and there is no further action to execute. This also tends to make for controlling and abusive personalities.

* Sociopaths are not necessarily sadists. The goal is not typically to harm other people, but rather to fulfill themselves irrespective of any harm.